IRF3 CLIA Kit for Bovine(Bos taurus) | EIAab.comIRF3 CLIA Kit for Bovine(Bos taurus)

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IRF3 (Gene name),

Interferon regulatory factor 3 (Protein name ), IRF3_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IRF3;

Protein name:

Interferon regulatory factor 3(IRF-3);

Alternative:

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Homodimer; phosphorylation-induced. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with RBCK1. Interacts with TRIM21. Interacts with HERC5.

Function:

Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.

Subcellular Location:

Cytoplasm Nucleus Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Protein Attributes:

Sequence length:

417

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

417:

PDQYMACLQD | LAEDMDF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q4JF28

Pfam:

PF00605

UniGene:

Bt.45332

String:

Q4JF28

KEGG:

bta:516979

Uniprot:

Q4JF28

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ELISA Kit for Bovine IRF-3

Cat.:

E1491m

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96T

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ELISA Kit for Bovine IRF-3

Cat.:

E1491h

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96T

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ELISA Kit for Bovine IRF-3

Cat.:

E1491b

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96T

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ELISA Kit for Bovine IRF-3

Cat.:

E1491c

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ELISA Kit for Bovine IRF-3

Cat.:

E1491p

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96T

CLIA Kit for Bovine IRF-3

Cat.:

U1491h

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MSDS:

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Packing:

96T

CLIA Kit for Bovine IRF-3

Cat.:

U1491m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Bovine IRF-3

Cat.:

U1491b

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MSDS:

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Packing:

96T

CLIA Kit for Bovine IRF-3

Cat.:

U1491c

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Packing:

96T

CLIA Kit for Bovine IRF-3

Cat.:

U1491p

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Packing:

96T

Polyclonal Antibody for Bovine IRF-3

Cat.:

P1491Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine IRF-3

Cat.:

P1491Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine IRF-3

Monoclonal Antibody for Bovine IRF-3

Protein for Bovine IRF-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Dissection of MyD88 dependent and independent TLR-mediated signal transduction in mammary epithelial cells of the cow."
Yang W. , Seyfert H.M.
Submitted (2005-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Mammary gland.
2.

"Stimulation of the MyD88-independent pathway in bovine antigen presenting cells."
Werling D.
Submitted (2005-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

Goodbourn S. , Moganeradj K. , McCauley J.
Submitted (2007-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2005-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Crossbred X Angus.
tissue: Ileum.

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